Adam Kleinschmit Ph.D.
Assistant Professor of Biology
206 Porter Hall
- B.S. University of Wisconsin, Madison
- Ph.D. University of Minnesota, Twin-Cities
- Introductory Biology
- Cell Biology
- Molecular Biology
- Developmental Biology
- Cellular Biology
- Molecular Biology
My research interests include understanding
how cells communicate during developmental patterning within multicellular
organisms. More specifically,
investigating the molecular basis of developmental signaling and its role in
controlling cell growth, differentiation, and tissue patterning in the fruit
fly; Drosophila melanogaster. Studying such signaling cascades in a model
organism, such as the fruit fly, allows for use of a powerful and well
developed genetic toolbox, which can be used to manipulate the pathway in
question. A better understanding of
fruit fly developmental signaling pathways, which are often highly conserved
across taxa, will shed light on human disease, including cancer.
Additionally, I am interested in functional genomic approaches to understanding gene function and protein interactions. Currently, my students and I are actively participating in the Genomics Education Partnership (GEP), which is an international collaboration between a number of collegiate institutions and Washington University in Saint Louis. Students undertake projects, which include improving draft-quality genomic sequence up to finished-quality as well as the annotation of the genetic elements within these sequences. Original data generated by students is uploaded to publically available databases for use by the scientific community. Currently this data is being used by the laboratory of Sarah Elgin at Washington University, where GEP is housed, for an investigation into the differences between heterochromatin and euchromatin by using a comparative genomics approach across Drosophila species.
- Dejima, K., Kleinschmit, A., Takemura, M., Choi, P. Y., Kinoshita-Toyoda, A., Toyoda, H., & Nakato, H. (2013). The role of Drosophila heparan sulfate 6-O endosulfatase in sulfation compensation. Journal of Biological Chemistry, 288(7), 6574-6582.
- Kleinschmit, A., Takemura, M., Dejima, K., Choi, P. Y., & Nakato, H. (2013). Drosophila Heparan Sulfate 6-O-Endosulfatase Sulf1 Facilitates Wingless (Wg) Protein Degradation. Journal of Biological Chemistry, 288(7), 5081-5089.
- Kleinschmit, A., Koyama, T., Dejima, K., Hayashi, Y., Kamimura, K., & Nakato, H. (2010). Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation. Developmental biology, 345(2), 204-214.